AICAR (Acadesine) 50 mg by QRP Nutrition: A Research-Grade Metabolic Modulator

In the world of performance and metabolic research, AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) has garnered attention for its unique ability to activate cellular energy sensors and enhance endurance. QRP Nutrition’s AICAR QRP Nutrition 50mg vial offers a pharmaceutical-grade, lyophilized powder—ideal for researchers and qualified biohackers exploring its effects on AMPK pathways, mitochondrial biogenesis, and metabolic health.

What Is AICAR?

AICAR is a synthetic analogue of AMP that activates AMP-activated protein kinase (AMPK), the central regulator of cellular energy balance. By mimicking a low-energy state, AICAR prompts cells to:

• Improve glucose uptake and insulin sensitivity
• Enhance fatty acid oxidation
• Stimulate mitochondrial biogenesis, increasing endurance potential
• Switch metabolic preference toward energy-efficient pathways

Originally investigated for ischemia–reperfusion injuries and cardioprotection, AICAR is now widely used in metabolic and exercise physiology studies.

Research-Backed Benefits

1. Endurance & Performance
   • Animal models demonstrate up to a 44% increase in running capacity via upregulated mitochondrial enzymes.
2. Metabolic Health
   • Enhances insulin sensitivity and glucose disposal in diabetic and obese rodent models.
3. Cardiovascular Protection
   • Activates protective signaling in cardiac muscle under stress conditions.
4. Muscle Fiber Transformation
   • Promotes a shift toward oxidative (Type I) muscle fibers, favoring endurance.

QRP Nutrition’s 50 mg AICAR: Quality & Purity

• > 99% purity confirmed by HPLC and mass spectrometry
• Produced in GMP-certified facilities with rigorous batch testing
• Supplied as sterile, lyophilized powder in airtight, depyrogenated vials
• Certificate of Analysis (CoA) available on request for each batch

⚖️ Suggested Research Protocol

Disclaimer: AICAR is intended for laboratory and investigative use only. Consult institutional guidelines before handling.

1. Reconstitution
   • Dissolve 50 mg of AICAR in 2 mL bacteriostatic water to create a 25 mg/mL solution.
2. Dosage Framework
   • Common subcutaneous research dose: 0.3–1.0 mg/kg body weight daily.
   • Split dose (morning and pre-exercise) to maintain AMPK activation.
3. Study Duration
   • Typical cycles range 2–8 weeks, followed by washout periods to assess reversible effects.

⚠️ Safety Considerations & Side Effects

• Transient Effects: Mild fatigue or GI discomfort reported in isolated preclinical cases.
• Long-Term Data: Human clinical studies remain limited; caution advised in subjects with cardiovascular or metabolic disorders.
• Receptor Dynamics: Prolonged AMPK activation may require cycling protocols to prevent adaptive downregulation.

Why QRP Nutrition?

• Scientific Rigor: Transparent documentation and independent third-party testing
• Global Reach: Discreet, temperature-controlled shipping for accredited laboratories worldwide
• Expert Support: Protocol guides, dosing calculators, and peer-reviewed literature references

Conclusion

QRP Nutrition’s AICAR 50 mg provides a high-purity, research-grade tool for probing the AMPK pathway and its downstream effects on endurance, metabolism, and cellular health. Whether your focus is on exercise physiology, metabolic disease models, or cardioprotection studies, this formulation delivers consistent quality and reliability. As always, responsible use under appropriate ethical and institutional oversight ensures the integrity and safety of your research.

This article is for informational and research purposes only and does not constitute medical advice.